Largest Generic Pharmaceutical Companies In The World - Our 20th anniversary list highlights booms fueled by brand revivals, new ratings battles and M&A, but looking back at the numbers in the shadow of COVID-19 is a different story.
Brand promotions, new rating battles and M&A-driven growth highlight Pharm Exec's annual list of the best global biopharmaceuticals, but behind the numbers, in the shadow of COVID-19, is another story that reinforces the broader health of the industry. mission
Largest Generic Pharmaceutical Companies In The World
While the focus of the world today is, of course, the global crisis of COVID-19—and the critical response, resources, and research efforts for governments, the health and medical communities, and others to end the pandemic—it may seem. A peculiar juxtaposition to highlight the annual list of the 50 best-selling biopharmaceutical manufacturers.
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Or could this background offer a very real context or perspective for this year's 20th notebook? The scale and power required to fight not only diseases like cancer or chronic diseases, but also unexpected viral disasters like COVID-19 has never been more evident than today; Before Ebola, Swine Flu and HIV/AIDS; and the next epidemic is coming.
After all, many of the companies on our list are on the front lines of the current crisis, through avenues such as treatment, education, training and research (see here), and likely the next. Some have launched their own initiatives, many work side-by-side (such as the 12-organization COVID-19 Therapeutics Accelerator Consortium in the Pharma 50), and others partner with government (such as Operation Warp Speed, US Department of Health). the . Health and Human Services Agreement with AstraZeneca to accelerate the development and production of a coronavirus vaccine developed by the University of Oxford.
The sum of annual prescription drug revenue and R&D spending demonstrates these companies' ability to co-produce products and support investments that result in new science and promising innovation. One such example is Pfizer's announcement earlier this month that they will commit $500 million to a range of clinical-stage biotechs and allow Pfizer's resources to be used in research, clinical development and manufacturing.
Based on the latest full-year drug revenue estimates, COVID has no financial impact on the latest Pharma 50 rankings. However, the top 10 positions experienced the biggest shake-up in recent years, partly due to a couple of mega-mergers. Roche climbed one spot with Rx sales up 8.3%, ending Pfizer's four-year lead. Avastin, which accounts for 15% of the company's total pharmaceutical revenue, remains Roche's best-selling product, but will face biosimilar competitors such as Herceptin and Rituxan in the coming years. Once the boosters arrive, Roche's key sales include multiple sclerosis drug Ocrevus, hemophilia drug Hemlibra, and cancer treatments Tecentriq and Perjeta. In recent times, it has been rare for the Pharma 50 to have the same company top both drug revenue and R&D spending, with Roche in second place with $10.3 billion in total value and $1 billion in R&D investment. dollar figures.
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The data of the Pharma 50 list is presented again in cooperation with the life science market research company Evaluate Ltd. Click on the table below for details on how the lists are calculated.
Novartis moved up one place from our previous ranking, moving from third to second place thanks to a 6 percent increase in drug sales. In January, big pharma completed its $9.7 billion acquisition of The Medicines Company, adding inclisiran, a potential No. 1 cholesterol-lowering therapy (which uses the body's natural mechanisms to turn off RNA). Novartis' heart failure drug Entresto grew 74 percent year-over-year to $1.7 billion in the fourth quarter of 2019; In the first quarter of 2020, its total value was 569 million dollars. The Zolgensma gene therapy, which received a lot of attention last June due to spinal muscular atrophy, received continuous market momentum, as payers did not refrain from supporting the single-dose treatment despite the burden. price tag.
Pfizer, Merck & Co. are among the top five Pharma 50. and Bristol Myers Squibb. Pfizer fell two spots as Rx sales fell 3.6%, partly due to a fourth-quarter decline in its nerve pain drug Lyrica, which has several competitive generic versions. Sales of its breast cancer treatment Ibrance rose 20.5 percent last year, and Pfizer, which completed its $11.4 billion acquisition of cancer-focused Array BioPharma in July 2019, has other products such as Eliquis, Xeljanz, Xtandi and Inlyta . woman. Anticipated launches such as Vyndaqel/Vyndamax, Braftovi, Mektovi and oncology biosimilars. Merck Rx sales rose 9.5%, up 54.5%, to $11.1 billion as its cancer immunotherapy drug Keytruda continues to gain approval for new indications.
BMS rose from No. 11 to No. 5 as our list is influenced by the Rx sales consensus of Celgene, which was officially acquired in November for $74 billion after the deal was announced last January. Celgene's multiple myeloma drug, Revlimid, led overall revenue with sales of nearly $11 billion, and BMS Eliquis followed with 23 percent year-over-year growth. BMS says COVID-19 demand for its blood thinner, which it makes in partnership with Pfizer, boosted revenue by 37% to $2.6 billion in the first quarter of 2020. BMS and Celgene together spent about $9.4 billion on R&D last year. In this indicator, it took second place, while Johnson & Johnson and Merck took third and fourth place, respectively. Earlier this year, Brand Finance, an independent brand valuation consultancy, named J&J the 2020 Most Valuable Pharmaceutical Company due to J&J's strong R&D investments, particularly in antimicrobials. J&J was one of the first to announce the development of a vaccine against the coronavirus during the Chinese epidemic.
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As expected, Takeda Pharma made the top 10 of the 50, moving from 16th to 10th thanks to the integration of Shire. The Japanese Rx drug maker's revenue rose 67.8 percent in the first year after its $62 billion acquisition.
While AbbVie (8th) completed its $62 billion acquisition of No. 18 Allergan last month, putting AbbVie in the top five for the next year or two, COVID-19 has halted many healthcare M&A completions. hit before the epidemic. According to Vantage, recent deals, such as the March purchase of cancer biotech Gilead, were made before the full extent of the crisis was likely understood, if not threatened. Still, M&A uncertainty aside, big pharma earnings will remain relatively high for the rest of 2020 amid the coronavirus pandemic.
(and the upcoming US presidential election in November). Evaate Vantage noted that Merck was the only company to cut full-year guidance ($1.7 billion) in mid-May. In addition to BMS, Novartis, GSK and Lilly were also among those who reported a significant increase in demand in 2020.
Outside the top 10, notable observations from the rest of the Pharma 50 field include Japan-based Astellas Pharma climbing four places to 19th, and four more Asians joining our list (Meiji Holdings, Japan, 27th; Yunnan Baiyao Group, China, 37. Shanghai Pharmaceutical Holdings, China, 48; Aurobindo Pharma, India, 50) and Regeneron Pharmaceuticals rose from 38 to 31 on the back of 18% growth in Rx sales (the New York biotechnology also increased its research and development expenses by 19% 17.).
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Not surprisingly, the COVID-19 pandemic—and the resulting public health restrictions and state and national quarantine measures—has caused significant disruptions to new and ongoing clinical development research.
Illnesses not related to COVID. Meanwhile, research into COVID therapies and vaccines has been fast and furious, with many projects clashing with necessary deadlines. III published this month regarding Gilead's experimental treatment. Phase I clinical trial data showed the efficacy of remdesivir, which was used under FDA emergency use authorization. The results showed that the drug was more effective in patients who received a five-day course of treatment than in those who received twice as much remdesivir or those who received standard care. Complete
More than 175 vaccine candidates are under investigation in various technologies. Moderna Therapeutics' mRNA-1273 may be the top contender at the moment, but big pharma is sure to be heavily involved in development and manufacturing. In addition to AZ and J&J, other important vaccine projects were launched by Merck, Pfizer, Sanofi and GSK.
Regeneron is developing an "antibody cocktail" to treat the coronavirus, and Roche's COVID-19 antibody test, which was approved for emergency use last month, could go live in more than 200 U.S. commercial and hospital laboratories in the coming weeks.
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The Torreya Pharma 1000 report provides a snapshot of the global pharmaceutical industry in September 2020 and compares it to the industry in 2015. We rank the top 1,000 companies by value to make it easier to compare the economic value of otherwise significantly different companies.
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