23 And Me Or Ancestry Com

23 And Me Or Ancestry Com - I just got my results from a commercial ancestry result test like 23andMe and it shows that I am 94% W Asian and 1% E Asian. Does this mean that there is only 1% gene flow in some East Asian populations?

You would think this is not right, especially if you are a W Asian with E Asian physical features. You do some research online and read on blogs and forums that a phenotype is not the same as a genotype. You are skeptical of this statement because you are well aware that if phenotype is not the same as genotype, then why do Chinese people not have arbitrary facial shapes like Africans or NW Europeans?

23 And Me Or Ancestry Com

The statement that the phenotype is not the same as the genotype is false, and you correctly conclude that there must be some relationship between the two that causes people with the "Chinese" genotype to have a "Chinese" phenotype rather than a "Northwest European" phenotype.

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Then we wonder if there is a correlation between phenotype and genotype, and considering EAsian face shape, why 23andMe's results don't show more than 1% EAsian.

The answer is a 1% E Asian result out of 23 and Me is not a full E Asian mix. 1% reflects the E Asian mix, excluding W Asian references used by 23andMe.

Indeed, even these W Asian contexts have older E Asian admixtures integrated into their genomes. A way to determine the amount of ancient Asian admixture contained in the 23andMe Asian reference genome is to use ancient Asian references such as Neolithic Near Eastern or European farmers predating the Iron Age or Medieval Asian gene flow. W Asia.

If you want to determine the total Asian admixture in UK testers, you can use Neolithic English farmers as a baseline using admixture-based tests or formal statistical tests.

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There's another reason why the 23andMe test underestimates Asian blends. 23andMe divides the genome into 100bp windows. The algorithm declares segment E Asian only if the 100 bp window contains most of the E Asian haplotype. That is, if there is a 40 bp E Asian haplotype associated with previous admixture, it will be ignored in the 23andMe test.

Therefore, the 23andMe test ignores older Asian admixtures included in the W Asian context, as well as other older Asian admixtures that correlate with haplotypes less than 50 bp in length.

Here we attempt to quantify the total amount of small E Asian-like admixture in Kurds-like W Asian subjects, using both modern and ancient contiguous populations as W Eurasian baselines.

We start with 23andMe results for two Kurmanji Kurdish subjects, each with four Kurdish grandparents from the Kurdistan region of Northern Iraq. They are called Kurd-K1 and Kurd-K3. Most Kurds-SE are descendants of the Balochistan Kurds of Iran, the Kurds of Iraq, and the Baloch tribes of Iran.

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If you believe the results from 23andMe, you would think that Kurds K1 and K3 have 1% and 0.8% EAsian admixture respectively, while Kurd-SE only has 6.8% EAsian admixture.

Of course not. So, you ask, where is the rest of the Asian mixture hiding? Well, some of them were removed by 23andMe's "smoothing" algorithm, when Asian haplotypes shorter than 50 bp in length were generally associated with older admixtures and discarded.

The rest of the Asian mix is ​​included in the Persian, Turkish and Caucasian individual genetic makeup that make up 23andMe's "West Asian" references.

So how do we figure out this East Asian mix with Persian, Turkish and Caucasian references? Well, we don't use them as a reference to the West Asian component. Instead, we use references that are less East Asian in their own right. For example, in the Neolithic Near Eastern farmers who predated all recent pulses of East Asian admixture in the Near East, or in a calculator based on the current situation, we might use the Bedouin, a Caucasian less East Asian than a Persian. , Turkish context.

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Here are the results obtained when designing a K5 admixture-based calculator (observation mode) using the following component references from the public data set:

The K-5 admixture run reveals about 9% Mongolian admixture and about 9% South Asian admixture for Kurd-K1 and K3, but their 23andMe results show only about 1% of this ancestry.

Similar to the case of the Kurd-SE, the K-5 run shows approximately 21% Mongolian ancestry and 17% South Asian admixture. 23andMe shows 6.8% East Asian and about 40% South Asian mixed race. Pania was used as a South Asian reference in the K-5 run, and NW South Asians and Afghans were included in 23andMe's South Asian reference. Editor's Note: I've included a full list of added territories and countries. The Lineage configuration report is at the end of this post.

DNA is the blueprint and record of life, and as our understanding of genetics advances, we will learn more about what is written in each blueprint.

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23andMe has improved its interactive Ancestry Composition report, significantly improving your ability to look deeper into your genetic roots, connect with other populations around the world, and learn more about yourself.

This new update, which customers will see in the coming months, compares you to more than 150 populations and regions around the world to visualize the geographic origin of your DNA.*

We all have a DNA story, and that story is part of the broader human story. It has a history of people who migrated from Africa to inhabit the world and build new cultures. The footsteps of those ancestors can be seen in your DNA. Over thousands of years, as different groups of people diverged from each other to new frontiers, small genetic changes occurred that provide tiny clues about our history.

We can find these clues by looking at the DNA segments of the genome, comparing those segments in relation to populations in Europe, Asia, Americas, Oceania, the Middle East and Africa.

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Traditionally, the Ancestry Composition report has compared customer data to 31 different populations, allowing 23andMe to report the percentage of DNA from that region. This helped connect individuals to their ancestors 500 years before the advent of modern migration.

With this new update, we still make these estimates, but add another layer of insight that holds clues to the location of our more recent ancestors. We do this by finding exact DNA matches between our clients and over 130,000 individuals of known ancestry in 120 locations worldwide.

If an individual exactly matches 5 or more individuals in a specific region, that region is assigned a "most recent ancestor location". We also report the "strength" of the match. This is determined by the amount of DNA your customer shares with people in your area, based on how many people are included in your reference population.

We're excited to release this update to our already incredibly powerful interactive tool for exploring your ancestors. Besides a significant increase in the number of regions, the update also includes map improvements. It also enhances the panning and zooming experience in geographic areas connected via DNA. We also relabeled some populations for accuracy and better understanding. For example, Yakut has been relabeled as Siberian. Taken together, these changes to 23andMe's Ancestry Composition Report provide a better way to visualize ancestry. As with all features and reports we provide to our clients, this includes details on the science behind our tools so you know how these estimates are made.

Ancestry Dna Vs 23andme Results Of An Argentinian

In addition to what Ancestry Composition offers, there are additional ancestry-related tools unique to the 23andMe experience. And these tools connect us to wider human stories and deeper histories.

These include the first report of Neanderthal ancestry and 23andMe's maternal and paternal haplogroup reports. Neanderthal ancestry reports offer another way to make your own connections to the human story. It shows how your DNA contains tiny pieces of DNA from our ancient human cousins, the Neanderthals.

23andMe's haplogroup report connects users to haplogroups, which are diverse lineages descended from a common ancient ancestor. As our ancestors migrated out of Africa, they split into different groups and crossed the globe over thousands of years. Links to ancient migrations can be traced by looking at haplogroups. 23andMe's haplogroup report provides insight into these ancient ancestors. These two reports connect us to our deepest ancestors by showing how they are connected to groups of people that have migrated around the world over thousands of years.

Another example of how much more you can learn by exploring your DNA is the update to the Ancestry Composition feature. new

How To Interpret Your Ancestry Admixture Results

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