Top 10 Pharmaceutical Companies Uk - The lack of vaccines and treatments for COVID-19 shook Pharm Exec's latest list of the world's top biopharmaceutical sellers in fashion records, but the possibility of leveling - along with challenging patents and the global climate - should shift some focus to the expected increase. not infected with COVID-19. 19 and more precise forward maneuvers.
50 represents the past year - represents the scale of the pandemic and disruption to all aspects of life - then 2021 will definitely be the year of vaccines and treatments against COVID. And, through the prism of our latest ranking of the world's top 50 biopharma players based on prescription drug sales, that will go down in the history of commercial Rx manufacturing — even if we only look back a few decades from now. To reflect the historic upheaval of the pandemic in our annual list, reorganizing several spots in the top half, the first attention was the mRNA vaccine creators Pfizer and Moderna, and the former also produced new results from the effective, if somewhat controversial, antiviral therapy for COVID. In data submitted again in partnership with Evaluate Ltd, the ranking, our 22nd, reflects the drug's most recent full-year revenue performance. The company's total investment in research and development is also presented, as in previous installments.
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Last year, Pfizer recorded total sales of prescription drugs of $72 billion, of which $37 billion was generated from Comirnaty's Covid vaccine alone, making it the best-selling single-year drug of all time by a wide margin. Factor in Comirnaty's $13.2 billion in first-quarter revenue in 2022, and the vaccine, developed in partnership with German biotech BioNTech, has rivaled the cumulative lifetime sales of many blockbuster drugs. Paxlovid, Pfizer's COVID pill, which received emergency use approval from the FDA in December 2021, had sales of $1.5 billion in the first quarter and could become the best-selling non-vaccine vaccine if it meets Pfizer's $22 billion dollar guidance by 2022. . If production is ramped-up and the total proceeds, Paxlovid will surpass AbbVie's Humira in sales of $20.7 billion in 2021 as the highest-grossing non-vaccine to date. Those prospects have suffered recent setbacks, including the CDC's warning of a potential "rebound" of COVID after taking Paxlovide.
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Pfizer and Moderna are among a handful of biopharmas that have reaped unparalleled COVID rewards after successful development projects. Given the numbers above, it's no surprise that Pfizer jumped from eighth place in our previous company rankings to No. 1 in the latest book, posting a 102% increase in Rx sales. In fact, Comirnaty's performance alone would rank Pfizer ninth overall. In May, the pharmaceutical giant reported the best quarter in the company's history, with total revenue (not just Rx) of $25.6 billion; expects full-year 2022 revenue to be between $98 billion and $102 billion (although Pfizer slightly reduced its earnings per share for the year in adjusted first-quarter guidance).
It shares the stage of the mRNA platform in Moderna's COVID vaccine Spikevax, which launched the Cambridge, Mass.-based biotech. into the Pharma 50 for the first time on the back of sales of $17.7 billion in 2021. Moderna secured the No. 17 spot with $19.2 billion in total Rx revenue. The company sold $5.9 billion of its COVID-19 vaccine in the first quarter of this year, and in its May earnings call it maintained the organization's full-year guidance of $21 billion in Spikevax sales. Of note, the marketing authorization for Spikevax in Japan will transfer from Takeda to Moderna starting August 1, the two companies announced at the end of May.
Led by its monoclonal antibody treatment, REGEN-COV (Ronapreve), to prevent COVID symptoms, Regeneron jumped eight spots in the Pharma 50 to No. 20, with prescription drug sales up 118% to $12.1 billion. REGEN-COV, which is effective against early variants of COVID, will generate sales of $5.8 billion in 2021.
Notable pandemic-driven jumps in our rankings include AstraZeneca (AZ), whose Vaxzevria vaccine hit $4 billion in sales last year, helping the company launch a 41.5% increase in Rx sales up two spots to No. Gilead Sciences rose one place to No. and Johnson & Johnson (J&J), which posted $49.8 billion in Rx sales in 2021, secured fourth place on our list and grew 15.5% year-over-year. The company's COVID vaccine, sold by its Janssen unit, will earn $2.39 billion in 2021.
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Our rankings next year may include treatments or vaccines approved for immediate use or use in the US and/or Europe in late 2021/early 2022 from Eli Lilly, Merck, GSK and Sanofi. (For example, revenue from Lilly's COVID antibodies, bamlanivimab and etesevimab, rose $660 million in the first quarter of this year; the duo earned $2.2 billion in 2021, and Merck's oral antiviral molnupiravir $3.2 billion in the first quarter).
The million dollar (or billion dollar) question is how long the ongoing headwinds will last. The consensus among analysts is that the first products cleared during the pandemic may have peaked, or will this year, and sales are likely to decline from there. But the appropriate context must also be weighed into the equation - after all, the pandemic represents a special and unexpected situation for the life sciences and healthcare sectors, which leads to an unprecedented response in research and development and ultimately in the distribution and delivery of products; therefore, comparing sales of COVID products with other drugs in the traditional sense may not be a fair exercise.
The potential of new records after this year, however, is not possible in the near future. Editors at Evaluate Vantage were interviewed
They cite trends such as declining demand for vaccines and COVID drugs, as well as supply challenges and changes in where future government contracts will primarily come from. "I think most of the developed western world that can afford to pay the higher prices have bought their vaccine stocks," said Lisa Urquhart, editor of Evaluate Vantage, which is based in London. "There is a debate [in the UK] about whether there will be a need for a fourth [dose] of the vaccine beyond the immunocompromised and vulnerable. If the US follows suit and the new strain continues the trend of softer growth, then I think some sales targets will not be met. It also means that you should now start selling outside the Western world to emerging markets where your margins will be lower.
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The consensus for Comirnaty sales in 2023 is reported to be around $17 billion. Estimated project revenues for Comirnaty and Paxlovid to be between $2 billion and $4 billion, respectively, by 2025. In the more immediate outlook for Paxlovid, Urquhart points to the uncertainty surrounding the number of new contracts signed in the first quarter and how much ground it will have to make up Pfizer's full year $22 billion target. He also noted the rather strict use of Paxlovide, with some contraindications, such as diabetes and hypertension. The consensus for Moderna's Spikevax, Evaluate said, is around $2 billion in annual sales by 2026. The company's post-COVID strategy will be closely watched (Moderna's pipeline includes candidates in Phase III trials for respiratory syncytial virus, and early-stage. projects for influenza and cancer, and finding the next generation in COVID).
AZ executives earlier this year predicted a decline for Vaxzevria in the low to mid-20s of 2022 (although the company is actively pursuing research and development of new antibodies), and in April J&J reported first-quarter sales of its vaccine of $457 million, far short of Wall's estimate Street. The result, caused by low demand and oversupply in low-income countries, led J&J to pull the vaccine from its revenue projections. Regeneron did not report first-quarter US sales for REGEN-COV after the FDA revoked its approval in January due to poor performance against omicron. Roche, which sells the drug outside the US in a profit-sharing arrangement with Regeneron, reported revenue of $636 million during the period.
Add to the mix ongoing macroeconomic challenges to navigate, such as the war in Ukraine, supply chain issues caused by China and global inflation; a volatile M & A and valuation climate sell that has shown little sign of abatement; and disruptive "patent season," which analysts say will be the most painful period of brand-name sales erosion at least 30 years, and the overall picture for Pharma 50 may be somewhat unsettled as the decade wears on.
Driven by COVID vaccines and therapies, US pharmaceutical spending rose 12% last year, according to a report by the IQVIA Institute for Human Data Science, and new prescription rates for chronic and acute care largely recovered from the weakness caused by the pandemic in 2020. … To that end, several organizations that did not have a COVID product in our ranking produced solid results in Rx sales in 2021, not more than the strong increase made by AbbVie. Prescription drug revenue for the North Chicago-based drugstore surged to nearly $11 billion
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